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As bacterial antibiotic resistance continues to exhaust the supply
of effective antibiotics, a global public health disaster appears
likely. Poor financial investment in antibiotic research has
exacerbated the situation. A call to arms - raised by several
prestigious scientific organizations a few years ago - rallied the
scientific community and now the scope of antibacterial research
has broadened considerably. Multi-disciplinary approaches have
yielded a wealth of new data on areas ranging from the
identification of novel antibacterial targets to the use of
biological agents for antibacterial therapy. In this book,
respected international experts summarize the most important
concepts and pioneering strategies currently being used to develop
novel antibacterials. The book opens with chapters on cellular
processes that could be used as novel antibacterial targets.
Examples include cell division, efflux pumps, metabolite-sensing
riboswitches, and bacterial secretion systems. These are followed
by excellent chapters on the identification of new, naturally
occurring antibacterial agents, including phage and
biosynthetically engineered compounds. Understanding the
host-microbe interaction and microbial communities and how they can
be exploited to develop new antibacterial strategies is discussed
in subsequent chapters. Other topics include antibacterial vaccines
adjuvants, host defense peptides, antibodies, within-host models,
and diagnostics.
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